International Journal of Pharma and Bio Sciences ISSN 0975 - 6299 NATIONAL CONFERENCE ON “ Recent Trends in Industrial Pharmacognosy ” “ RTIP - 2012 ”

Phytomedicine for wound healing are not only cheap and affordable but are also purportedly to be safe as hypersensitive reactions are rarely encountered with the use of these agents. Passiflora foetida is reported to possess anti-inflammatory, anti-ulcer, anti-oxidant activities. It is reported that traditionally its leaves used in the wound healing treatment. Thus, the study was carried out to evaluate its wound healing potential scientifically. Methodology: In this study, Passiflora foetida leaves were extracted with different solvents which include petroleum ether, chloroform, ethanol and water. Antibacterial activity of the extracts was screened against various microorganisms using Amikacin 30 mcg as standard. Then, the plant extracts were formulated as herbal creams with aqueous base. The wound healing effect of herbal creams formulated with Passiflora foetida leaf extracts embedded in aqueous cream base has been evaluated in vivo using the excision wound healing model and linear incision wound healing model, on wistar rats. The herbal creams were used to treat wounds inflicted on experimental rats. Results and discussion: Antibacterial study revealed that the extracts were having good antibacterial activity against microorganisms tested. The wound healing effects of the formulations were compared to that of a standard (5 % w/w Povidone iodine ointment). In all cases, there was a progressive decrease in wound area with time, indicating an efficacy of the formulations in healing the induced wounds. By the 8 th day, the cream containing ethanol extract of Passiflora foetida leaves in aqueous cream base showed 100 % healing. The wound areas in the animals treated with the ORAL-01